| Rank | Time | Student | Grade | School | Year | |
| 1 | 17:12.70 | Natalie Barnard | Sr | Lafayette (Wildwood) | 2023 | Class 5 |
| 2 | 17:14.22 | Taylor Werner | Sr | Ste. Genevieve | 2015 | Class 3 |
| 3 | 17:31.30 | Taylor Werner | So | Ste. Genevieve | 2013 | Class 3 |
| 4 | 17:37.29 | Elyse Wilmes | Jr | Father Tolton Regional Catholic | 2023 | Class 5 |
| 5 | 17:38.29 | Hannah Long | Sr | Eureka | 2014 | Class 3 |
| 6 | 17:40.90 | Mary McKenzie | So | Cor Jesu Academy | 2023 | Class 5 |
| 7 | 17:42.90 | Grace Tyson | Jr | Lafayette (Wildwood) | 2021 | Class 5 |
| 8 | 17:46.72 | Anna Marie West | Sr | Lafayette (Wildwood) | 2015 | Class 4 |
| 9 | 17:46.82 | Hannah Long | Jr | Eureka | 2013 | Class 4 |
| 10 | 17:51.40 | Merideth Snow | Sr | Eureka | 2005 | Class 4 |
| 11 | 17:54.60 | Josie Baker | Sr | Kirkwood | 2023 | Class 5 |
| 12 | 17:56.00 | Emily P. Sisson | Sr | Parkway Central | 2009 | Class 4 |
| 13 | 17:56.50 | Leah Kleekamp | Sr | Eureka | 2021 | Class 5 |
| 14 | 17:57.00 | Emily P. Sisson | Jr | Parkway Central | 2008 | Class 4 |
| 15 | 17:57.20 | Amelia Arrieta | Sr | St. Teresa's Academy | 2021 | Class 5 |
| 16 | 17:57.60 | Abigail Brackenbury | Sr | Blue Springs | 2023 | Class 5 |
| 17 | 17:59.64 | Samantha Nicole Nightingale | Jr | Blue Springs South | 2010 | Class 4 |
| 18 | 17:59.90 | Jamie Elizabeth Kempfer | Sr | Festus | 2013 | Class 3 |
| 19 | 18:00.00 | Julia Ray | Jr | MICDS | 2021 | Class 5 |
| 20 | 18:01.56 | Sarah Jane Nicholson | Sr | Lafayette (Wildwood) | 2015 | Class 4 |
| 21 | 18:02.26 | Mikayla Reed | Jr | Washington | 2016 | Class 4 |
| 22 | 18:03.10 | Ally Kruger | Jr | Liberty (Wentzville) | 2020 | Class 5 |
| 23 | 18:03.90 | Mya Trober | Sr | Blue Springs | 2021 | Class 5 |
| 24 | 18:05.51 | Samantha Nicole Nightingale | Sr | Blue Springs South | 2011 | Class 4 |
| 25 | 18:06.70 | Ally Kruger | Sr | Liberty (Wentzville) | 2021 | Class 5 |
| 26 | 18:06.91 | Hannah Long | So | Eureka | 2012 | |
| 27 | 18:07.18 | Victoria Ann Findley | So | Blue Springs South | 2015 | |
| 28 | 18:09.01 | Sophia Racetta | Sr | Nerinx Hall | 2014 | |
| 29 | 18:09.34 | Victoria Ann Findley | Sr | Blue Springs South | 2017 | |
| 30 | 18:09.49 | Jessica Robin Jackson | Sr | Neosho | 2010 | |
| 31 | 18:13.14 | Hannah Pierson | Jr | Marquette | 2014 | |
| 32 | 18:15.45 | Grace Ellen Klausen | Sr | Blue Springs South | 2014 | |
| 33 | 18:16.80 | Megan Thompson | Sr | Hazelwood Central | 1989 | |
| 34 | 18:19.88 | Taylor Werner | Fr | Ste. Genevieve | 2012 | |
| 35 | 18:20.06 | Anna Marie West | Jr | Lafayette (Wildwood) | 2014 | |
| 36 | 18:20.20 | Jill Whitman | Sr | Cor Jesu Academy | 2013 | |
| 37 | 18:20.50 | Susan Bliss | Sr | Francis Howell | 1987 | |
| 38 | 18:27.60 | Riley Bryan | | Smithton | 2021 | Class 1 |
| 39 | 18:40.97 | Kaitlyn Fischer | | Herculaneum | 2012 | Class 2 |